Ion channels and transporters in cancer. 4. Remodeling of Ca signaling in tumorigenesis: role of Ca transport
نویسندگان
چکیده
Lee JM, Davis FM, Roberts-Thomson SJ, Monteith GR. Ion channels and transporters in cancer. 4. Remodeling of Ca signaling in tumorigenesis: role of Ca transport. Am J Physiol Cell Physiol 301: C969–C976, 2011. First published May 18, 2011; doi:10.1152/ajpcell.00136.2011.—The Ca signal has major roles in cellular processes important in tumorigenesis, including migration, invasion, proliferation, and apoptotic sensitivity. New evidence has revealed that, aside from altered expression and effects on global cytosolic free Ca levels via direct transport of Ca , some Ca pumps and channels are able to contribute to tumorigenesis via mechanisms that are independent of their ability to transport Ca or effect global Ca homeostasis in the cytoplasm. Here, we review some of the most recent studies that present evidence of altered Ca channel or pump expression in tumorigenesis and discuss the importance and complexity of localized Ca signaling in events critical for tumor formation.
منابع مشابه
Ion channels and transporters in cancer. 4. Remodeling of Ca(2+) signaling in tumorigenesis: role of Ca(2+) transport.
The Ca(2+) signal has major roles in cellular processes important in tumorigenesis, including migration, invasion, proliferation, and apoptotic sensitivity. New evidence has revealed that, aside from altered expression and effects on global cytosolic free Ca(2+) levels via direct transport of Ca(2+), some Ca(2+) pumps and channels are able to contribute to tumorigenesis via mechanisms that are ...
متن کاملEffects of curcumin on ion channels and transporters
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric), has been shown to exhibit a wide range of pharmacological activities including anti-inflammatory, anti-cancer, anti-oxidant, anti-atherosclerotic, anti-microbial, and wound healing effects. These activities of curcumin are based on its complex m...
متن کاملMitochondrial and ER Calcium Uptake and Release Fluxes and their Interplay in Intact Nerve Cells
Ionized free Ca (Ca) is a ubiquitous signaling ion that serves as the critical link between a variety of physiological stimuli and their intracellular effectors. Previous studies of reduced in vitro preparations have provided functional characterizations of various Ca channels, pumps and exchangers that regulate cellular Ca movements. However, little is known about the functional interplay betw...
متن کاملNew mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling.
Pulmonary arterial hypertension (PAH) is a severe and progressive disease that usually culminates in right heart failure and death if left untreated. Although there have been substantial improvements in our understanding and significant advances in the management of this disease, there is a grim prognosis for patients in the advanced stages of PAH. A major cause of PAH is increased pulmonary va...
متن کاملMolecular Signaling in Tumorigenesis of Gastric Cancer
Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies on multiple factors, including environmental and genetic characteristics. One of the most important environmental factors of GC occurrence is infection with Helicobacter pylori that is classified as class one carcinogens...
متن کامل